17.2 Nomenclature - Granulocyte immunology

The current HNA nomenclature is based on epitopes and allelic typing and this must be used for recording granulocyte-specific alloantigen and alloantibody specificities [Flesch, 2016].

Details of nomenclature for HNA alleles, epitopes and corresponding antibodies are shown in Tables 17.1.1 to 17.1.5.

Table 17.1.1: Current HNA nomenclature - HNA-1 system

Allele	Epitopes	Original name	Glycoprotein	CD
Allele FCGR3B*01	Epitopes HNA-1a	Original name NA1	Glycoprotein FcγRIIIb	CD CD16
Allele FCGR3B*02	Epitopes HNA-1b, HNA-1d	Original name NA2	Glycoprotein FcγRIIIb	CD CD16
Allele FCGR3B*03	Epitopes HNA-1b, HNA-1c	Original name SH	Glycoprotein FcγRIIIb	CD CD16
Allele FCGR3B*04	Epitopes HNA-1a	Original name Not applicable	Glycoprotein FcγRIIIb	CD CD16
Allele FCGR3B*05	Epitopes HNA-1bv (†)	Original name Not applicable	Glycoprotein FcγRIIIb	CD CD16

Table 17.1.2: Current HNA nomenclature - HNA-2 system

Allele	Epitopes	Original name	Glycoprotein	CD
Allele Unknown	Epitopes HNA-2	Original name NB1	Glycoprotein GP56-64kDa	CD CD177

Table 17.1.3: Current HNA nomenclature - HNA-3 system

Allele	Epitopes	Original name	Glycoprotein	CD
Allele SLC44A2*01	Epitopes HNA-3a	Original name 5b	Glycoprotein CTL-2	CD Not applicable
Allele SLC44A2*02	Epitopes HNA-3b	Original name 5a	Glycoprotein CTL-2	CD Not applicable
Allele SLC44A2*03	Epitopes HNA-3av (†)	Original name Not applicable	Glycoprotein CTL-2	CD Not applicable

Table 17.1.4: Current HNA nomenclature - HNA-4 system

Allele	Epitopes	Original name	Glycoprotein	CD
Allele ITGAM*01	Epitopes HNA-4a	Original name MARTᵃ	Glycoprotein CD11/18	CD CD11b
Allele ITGAM*02	Epitopes HNA-4bw (†)	Original name Not applicable	Glycoprotein CD11/18	CD CD11b

Table 17.1.5: Current HNA nomenclature - HNA-5 system

Allele	Epitopes	Original name	Glycoprotein	CD
Allele ITGAL*01	Epitopes HNA-5a	Original name ONDa	Glycoprotein CD11/18	CD CD11a
Allele ITGAL*01	Epitopes HNA-5bw (†)	Original name Not applicable	Glycoprotein CD11/18	CD CD11a

References

Flesch BK, Curtis BR, de Haas M, Lucas G, Sachs UJ (2016). Update on the nomenclature of human neutrophil antigens and alleles. Transfusion, 56, 1477–1479. https://doi.org/10.1111/trf.13575