Updates

The following table lists all updates to the Guidelines for the Blood Transfusion and Tissue Transplantation Services in the UK (Red Book) and its consitituent Donor Selection Guidelines (DSGs).

The linked Change Notification documents are issued to the UK Blood and Tissue Services (UKBTS) to indicate upcoming changes. Please note that the dates listed below indicate the formal publication of updated guidelines on the website. The implementation of these guideline changes is the responsibility of each UKBTS and may vary accordingly.

Change number	Title	Updated	Guidelines affected
Change notification number 19-2025	Title Infertility (PDF only, 241KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)Tissue (live)
Change notification number 26-2025	Title Weight Loss Medication (PDF only, 296KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 27-2025	Title Deferral after HAV, HBV and JEV vaccines (PDF only, 371KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 28-2025	Title Hepatitis C (PDF only, 254KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 29-2025	Title Accept and PCOS (PDF only, 342KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 25-2025	Title Red Cells and Plasma, Leucocyte Depleted (PDF only, 360KB)	Update date 7 August 2025	Guidelines affected Red book
Change notification number 23-2025	Title Dried Plasma, Leucocyte Depleted (PDF only, 248KB)	Update date 25 July 2025	Guidelines affected Red book
Change notification number 24-2025	Title Platelets, Apheresis, in Additive Solution and Plasma, Leucocyte Depleted (PDF only, 224KB)	Update date 25 July 2025	Guidelines affected Red book
Change notification number 12-2025	Title Removal of malaria risk in Georgia and Cape Verde (PDF only, 210KB)	Update date 18 July 2025	Guidelines affected Geographical index
Change notification number 13-2025	Title Injectable Pre-Exposure Prophylaxis (PrEP) for HIV prevention (PDF only, 279KB)	Update date 18 July 2025	Guidelines affected Whole blood
Change notification number 14-2025	Title Interpreters (PDF only, 381KB)	Update date 18 July 2025	Guidelines affected Whole bloodRed book
Change notification number 11-2025	Title Chapter 9.3 and Annex 1 (PDF only, 342KB)	Update date 23 May 2025	Guidelines affected Red book
Change notification number 10-2025	Title Autologous Blood Donation (PDF only, 244KB)	Update date 30 April 2025	Guidelines affected Red book
Change notification number 05-2025	Title Updates in the GDRI (PDF only, 329KB)	Update date 30 April 2025	Guidelines affected Geographical index
Change notification number 06-2025	Title Endoscopy (PDF only, 196KB)	Update date 30 April 2025	Guidelines affected Whole blood
Change notification number 07-2025	Title Memorial Tattoos (PDF only, 174KB)	Update date 30 April 2025	Guidelines affected Whole blood
Change notification number 08-2025	Title Topical Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (PDF only, 176KB)	Update date 30 April 2025	Guidelines affected Whole blood
Change notification number 09-2025	Title Table of Immunisations (PDF only, 578KB)	Update date 30 April 2025	Guidelines affected Whole bloodTissue (live)Tissue (deceased)Cord bloodBone marrow
Change notification number 04-2025	Title Clinical supervision at donor sessions (PDF only, 267KB)	Update date 28 February 2025	Guidelines affected Red book
Change notification number 03-2025	Title Hepatitis C testing of donors transfused before 1996 (IBI update) (PDF only, 211KB)	Update date 17 February 2025	Guidelines affected Whole blood
Change notification number 02-2025	Title Human Plasma for Fractionation, Cryoprecipitate Depleted, Leucocyte Depleted (PDF only, 230KB)	Update date 25 January 2025	Guidelines affected Red book
Change notification number 01-2025	Title Removal of Dengue risk in Italy (PDF only, 196KB)	Update date 17 January 2025	Guidelines affected Geographical index
Change notification number 45-2024	Title Hepatitis A (PDF only, 300KB)	Update date 26 November 2024	Guidelines affected Tissue (deceased)Tissue (live)
Change notification number 46-2024	Title COVID-19 vaccination (PDF only, 288KB)	Update date 26 November 2024	Guidelines affected Whole blood
Change notification number 47-2024	Title Topical Anti-Androgens (PDF only, 175KB)	Update date 26 November 2024	Guidelines affected Whole blood