Updates

The following table lists all updates to the Guidelines for the Blood Transfusion and Tissue Transplantation Services in the UK (Red Book) and its constituent Donor Selection Guidelines (DSGs).

For updates specific to each set of guidelines, see the relevant Updates page:

• Geographical Disease Risk Index
• Whole blood and components
• Tissue (deceased donors)
• Tissue (live donors)
• Bone marrow and peripheral blood stem cells
• Cord blood
• Red Book

The linked Change Notification documents were issued to the UK Blood and Tissue Services (UKBTS) to indicate upcoming changes. Please note that the dates listed below indicate the formal publication of updated guidelines on the website. For changes pending publication, see Upcoming changes to the guidelines.

The implementation of these guideline changes is the responsibility of each UKBTS and may vary accordingly.

Change number	Title	Updated	Guidelines affected
Change notification number 35-2025	Title GDRI Preliminaries (PDF only, 382KB)	Update date 6 November 2025	Guidelines affected Geographical index
Change notification number 30-2025	Title Hepatitis A (PDF only, 205KB)	Update date 30 October 2025	Guidelines affected Bone marrowCord blood
Change notification number 31-2025	Title Tropical Viruses (PDF only, 194KB)	Update date 13 October 2025	Guidelines affected Bone marrow
Change notification number 32-2025	Title Sexually Transmitted Disease (PDF only, 197KB)	Update date 13 October 2025	Guidelines affected Bone marrowTissue (deceased)Tissue (live)Cord blood
Change notification number 33-2025	Title France and Italy (PDF only, 778KB)	Update date 13 October 2025	Guidelines affected Geographical index
Change notification number 20-2025	Title Chronic Fatigue Syndrome (PDF only, 260KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)Tissue (live)
Change notification number 21-2025	Title Transgender and Non-Binary Individuals (PDF only, 226KB)	Update date 13 October 2025	Guidelines affected Tissue (live)Tissue (deceased)
Change notification number 22-2025	Title Injectable Pre-Exposure Prophylaxis (PrEP) for HIV prevention (PDF only, 293KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)Tissue (live)Bone marrowCord blood
Change notification number 16-2025	Title Eye Disease (PDF only, 190KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)
Change notification number 17-2025	Title Kidney Disease (PDF only, 180KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)
Change notification number 18-2025	Title Hormone Replacement and Sex Hormone Therapy (PDF only, 231KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)Tissue (live)
Change notification number 19-2025	Title Infertility (PDF only, 241KB)	Update date 13 October 2025	Guidelines affected Tissue (deceased)Tissue (live)
Change notification number 26-2025	Title Weight Loss Medication (PDF only, 296KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 27-2025	Title Deferral after HAV, HBV and JEV vaccines (PDF only, 371KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 28-2025	Title Hepatitis C (PDF only, 254KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 29-2025	Title Accept and PCOS (PDF only, 342KB)	Update date 28 August 2025	Guidelines affected Whole blood
Change notification number 25-2025	Title Red Cells and Plasma, Leucocyte Depleted (PDF only, 360KB)	Update date 7 August 2025	Guidelines affected Red book
Change notification number 23-2025	Title Dried Plasma, Leucocyte Depleted (PDF only, 248KB)	Update date 25 July 2025	Guidelines affected Red book
Change notification number 24-2025	Title Platelets, Apheresis, in Additive Solution and Plasma, Leucocyte Depleted (PDF only, 224KB)	Update date 25 July 2025	Guidelines affected Red book
Change notification number 12-2025	Title Removal of malaria risk in Georgia and Cape Verde (PDF only, 210KB)	Update date 18 July 2025	Guidelines affected Geographical index
Change notification number 13-2025	Title Injectable Pre-Exposure Prophylaxis (PrEP) for HIV prevention (PDF only, 279KB)	Update date 18 July 2025	Guidelines affected Whole blood
Change notification number 14-2025	Title Interpreters (PDF only, 381KB)	Update date 18 July 2025	Guidelines affected Whole bloodRed book
Change notification number 11-2025	Title Chapter 9.3 and Annex 1 (PDF only, 342KB)	Update date 23 May 2025	Guidelines affected Red book
Change notification number 10-2025	Title Autologous Blood Donation (PDF only, 244KB)	Update date 30 April 2025	Guidelines affected Red book
Change notification number 05-2025	Title Updates in the GDRI (PDF only, 329KB)	Update date 30 April 2025	Guidelines affected Geographical index