Updates

The following table lists all updates to the Guidelines for the Blood Transfusion and Tissue Transplantation Services in the UK (Red Book). The linked Change Notification documents are issued to the UK Blood and Tissue Services (UKBTS) to indicate upcoming changes.

Please note that the dates listed below indicate the formal publication of updated guidelines on the website. The implementation of these guideline changes is the responsibility of each UKBTS and may vary accordingly.

Change number	Title	Updated	Guidelines affected
Change notification number 02-2026	Title Removal of vCJD risk from blood component labels (PDF only, 183KB)	Update date 17 February 2026	Guidelines affected Red book
Change notification number 03-2026	Title Red Book Chapter 23 (PDF only, 869KB)	Update date 17 February 2026	Guidelines affected Red book
Change notification number 04-2026	Title Red Book Chapter 3.4 (PDF only, 315KB)	Update date 17 February 2026	Guidelines affected Red book
Change notification number 38-2025	Title Red Cells for Neonates and Infants, Leucocyte Depleted, Washed (PDF only, 255KB)	Update date 8 December 2025	Guidelines affected Red book
Change notification number 25-2025	Title Red Cells and Plasma, Leucocyte Depleted (PDF only, 360KB)	Update date 7 August 2025	Guidelines affected Red book
Change notification number 23-2025	Title Dried Plasma, Leucocyte Depleted (PDF only, 248KB)	Update date 25 July 2025	Guidelines affected Red book
Change notification number 24-2025	Title Platelets, Apheresis, in Additive Solution and Plasma, Leucocyte Depleted (PDF only, 224KB)	Update date 25 July 2025	Guidelines affected Red book
Change notification number 14-2025	Title Interpreters (PDF only, 381KB)	Update date 18 July 2025	Guidelines affected Whole bloodRed book
Change notification number 11-2025	Title Chapter 9.3 and Annex 1 (PDF only, 342KB)	Update date 23 May 2025	Guidelines affected Red book
Change notification number 10-2025	Title Autologous Blood Donation (PDF only, 244KB)	Update date 30 April 2025	Guidelines affected Red book
Change notification number 04-2025	Title Clinical supervision at donor sessions (PDF only, 267KB)	Update date 28 February 2025	Guidelines affected Red book
Change notification number 02-2025	Title Human Plasma for Fractionation, Cryoprecipitate Depleted, Leucocyte Depleted (PDF only, 230KB)	Update date 25 January 2025	Guidelines affected Red book
Change notification number 28-2024	Title Donor Adverse Events Severity Grading (PDF only, 266KB)	Update date 7 October 2024	Guidelines affected Red book
Change notification number 22-2024	Title Upper age limit for returning donors (PDF only, 126KB)	Update date 31 July 2024	Guidelines affected Whole bloodRed book
Change notification number 29-2024	Title Human Plasma for Fractionation (PDF only, 171KB)	Update date 17 May 2024	Guidelines affected Red book
Change notification number 05-2024	Title Red Book Chapter 21 and Annex 7 (PDF only, 364KB)	Update date 18 April 2024	Guidelines affected Red book
Change notification number 03-2024	Title Red Book Updates Batch 3 (PDF only, 2.29MB)	Update date 13 March 2024	Guidelines affected Red book
Change notification number 40-2023	Title Chapters 7 and 9 (PDF only, 381KB)	Update date 11 December 2023	Guidelines affected Red book
Change notification number 39-2023	Title Annex 7 (PDF only, 242KB)	Update date 2 November 2023	Guidelines affected Red book
Change notification number 16-2023	Title Red Book Updates Batch 2 (PDF only, 2.49MB)	Update date 4 September 2023	Guidelines affected Red book
Change notification number 22-2023	Title Red Book Annex 3.5 (PDF only, 241KB)	Update date 12 April 2023	Guidelines affected Red book
Change notification number 06-2023	Title Red Book Updates, Batch 1 (PDF only, 1.43MB)	Update date 13 February 2023	Guidelines affected Red book
Change notification number 33-2022	Title Chapter 8 (PDF only, 740KB)	Update date 22 June 2022	Guidelines affected Red book
Change notification number 09-2022	Title Plasma for Fractionation, Leucocyte Depleted (PDF only, 184KB)	Update date 2 March 2022	Guidelines affected Red book
Change notification number 10-2022	Title Convalescent Plasma (VCOV-19) (PDF only, 191KB)	Update date 2 March 2022	Guidelines affected Red book