Hepatitis of unknown origin - Whole blood and components

1. If:
   1. It is more than 12 months from recovery, and
   2. A test for anti-HBc will be performed, accept for donation or take samples for testing, as directed by local procedures, accept.
2. If the donor has undergone previous testing by the Blood Transfusion Service, accept.
3. If more than 24 months from recovery, accept.

Post-session review of results:

1. anti-HBc positive donors:
   Must not donate.
   
2. If the donor is negative for all HBV markers (HBsAg, screening HBV DNA and anti-HBc, accept.

Most hepatitis of unknown origin will have been due to hepatitis A or hepatitis E (or non-viral causes).

Additional testing for those who give a history of hepatitis between 12 and 24 months previously ensures anti-HBc testing is carried out, to exclude hepatitis B infection.

After 24 months, donation testing for anti-HBc will be carried out routinely, as it will be at least two years since the donor last gave a blood donation or samples for testing by the transfusion service. These guidelines will be revised if policy for anti-HBc testing changes.

• Hepatitis B

The 12-month deferral period is to avoid transmission of any infection through transfusion.

There are different rules for contact with someone who has had hepatitis B. These should be followed if the donor reports that a household or sexual contact was most likely to have had hepatitis B.