Eye disease - Bone marrow and peripheral blood stem cell

Essential information

Obligatory

1. Must not donate for bone marrow or PBSC if:
   1. Active ocular inflammation.
   2. History of malignancy.
   3. Ocular tissue transplanted.
      
      
2. Must not donate for PBSC if:
   1. History of inflammatory eye disease (e.g. uveitis, scleritis, iritis, episcleritis, conjunctivitis).
   2. Associated with severe or multisystem autoimmune disease.
   3. History of detached retina or any eye condition/injury that affects blood vessels of eye.
   4. History of bleeding or clots in the eye or retina such as optic neuritis, optic neuropathy, or autoimmune retinopathy

Discretionary

1. History of inflammatory eye disease:
   1. If transient viral conjunctivitis, which is fully resolved, accept.
   2. For others, where a clear infectious aetiology has been identified, and the inflammation is resolved, seek advice from Designated Clinical Support Officer.
      
      
2. If it is an isolated autoimmune inflammatory process, or if it is a recurring inflammation or increased risk or recurrence (e.g. HLA-B27) or exacerbation (toxoplasma chorioretinitis), accept for bone marrow only, subject to advice from Designated Clinical Support Officer.

Supporting information

See if relevant

• Autoimmune disease
• Central nervous system disease
• Glaucoma
• Infection, general
• Malignancy
• Ocular surgery
• Ocular tissue recipient
• Steroid therapy
• Tissue and cell allograft recipients

Additional information

Inflammatory eye disease can be due to:

• Infectious causes (e.g. toxoplasmosis, CMV, leptospirosis, tuberculosis)
• Isolated autoimmune or non-infectious (e.g. HLA-B27 associated, traumatic/sympathetic ophthalmopathy, drug induced)
• Associated with systemic diseases (e.g. Behçet's disease, arthritis, connective tissue diseases).

Infectious eye diseases can aggravate years after initial treatment and the role of G-CSF in response to infectious agents is not fully understood.

Uveitis has been reported as a side effect of G-CSF. A history of eye inflammation in association with systemic disease usually requires deferral due to the underlying condition. If such an association cannot be excluded at medical examination, consider bone marrow only. Acceptable for donation only by bone marrow method if recurring inflammation or increased risk for recurrence (e.g. HLA-B27).

Reason for change:

’Obligatory’ and ‘Discretionary’ sections expanded. ‘Additional Information’ section added.

Version details:

BM-DSG Edition 203 Release 54 (29 January 2024)