Appendix 4: Grading of selected central nervous system tumours (WHO 2016 classification)

Diffuse astrocytoma, IDH-mutant

II

Anaplastic astrocytoma, IDH-mutant

III

Glioblastoma, IDH-wildtype

IV

Glioblastoma, IDH-mutant

IV

Diffuse midline glioma, H3K27M-mutant

IV

Oligodendroglioma, IDH-mutant and 1p/19q-codeleted

II

Anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted

III

Pilocytic astrocytoma

I

Subependymal giant cell astrocytoma

I

Pleomorphic xanthoastrocytoma

II

Anaplastic pleomorphic xanthoastrocytoma

III

Subependymoma

I

Myxopapillary ependymoma

I

Ependymoma

II

Ependymoma, RELA fusion-positive

II and III

Anaplastic ependymoma

III

Angiocentric glioma

I

Chordoid glioma of third ventricle

II

Choroid plexus papilloma

I

Atypical choroid plexus papilloma

II

Choroid plexus carcinoma

III

Pineocytoma

I

Pineal parenchymal tumour of intermediate differentiation

II and III

Pineoblastoma

IV

Papillary tumour of the pineal region

II and III

Meningioma

I

Atypical meningioma

II

Anaplastic (malignant) meningioma

III

Medulloblastoma (all subtypes)

IV

Embryonal tumour with multi-layered rosettes, C19MC-altered

IV

Medulloepithelioma

IV

CNS embryonal tumour, NOS

IV

Atypical teratoid/rhabdoid tumour

IV

CNS embryonal tumour with rhabdoid features

IV

Dysembryoplastic neuroepithelial tumour

I

Gangliocytoma

I

Ganglioglioma

I

Anaplastic ganglioglioma

III

Dysplastic gangliocytoma of cerebellum (Lhermitte–Duclos)

I

Desmoplastic infantile astrocytoma and ganglioglioma

I

Papillary glioneuronal tumour

I

Rosette-forming glioneuronal tumour

I

Central neurocytoma

II

Extraventricular neurocytoma

II

Cerebellar liponeurocytoma

II

Schwannoma

I

Neurofibroma

I

Perineurioma

I

Malignant peripheral nerve sheath tumour (MPNST)

II, III and IV

Solitary fibrous tumour/haemangiopericytoma

I, II and III

Haemangioblastoma

I

Craniopharyngioma

I

Granular cell tumour

I

Pituicytoma

I

Spindle cell oncocytoma

I