Updates

The following table lists all updates to the Guidelines for the Blood Transfusion and Tissue Transplantation Services in the UK (Red Book). The linked Change Notification documents are issued to the UK Blood and Tissue Services (UKBTS) to indicate upcoming changes.

Please note that the dates listed below indicate the formal publication of updated guidelines on the website. The implementation of these guideline changes is the responsibility of each UKBTS and may vary accordingly.

Change number	Title	Updated	Guidelines affected
Change notification number 11-2022	Title Whole Blood, Leucocyte Depleted, For clinical studies (PDF only, 105KB)	Update date 2 March 2022	Guidelines affected Red book
Change notification number 12-2022	Title Cryoprecipitate, Pooled, Leucocyte Depleted, Extended Shelf-Life Post-thaw (PDF only, 199KB)	Update date 2 March 2022	Guidelines affected Red book
Change notification number 18-2021	Title Plasmapheresis Changes (PDF only, 929KB)	Update date 22 June 2021	Guidelines affected Red book
Change notification number 03-2021	Title Chapter 21 (PDF only, 367KB)	Update date 12 January 2021	Guidelines affected Red book
Change notification number 66-2020	Title Convalescent Plasma COVID-19 FFP, Leucocyte Depleted (PDF only, 435KB)	Update date 17 November 2020	Guidelines affected Red book
Change notification number 67-2020	Title Convalescent Plasma COVID-19 FFP Neonates and infants, Leucocyte Depleted (PDF only, 494KB)	Update date 17 November 2020	Guidelines affected Red book
Change notification number 35-2020	Title Whole Blood, Leucocyte Depleted, For Clinical Studies (PDF only, 479KB)	Update date 26 October 2020	Guidelines affected Red book
Change notification number 47-2020	Title Platelets, Apheresis, Leucocyte Depleted, Reduced Dose as Contingency (PDF only, 463KB)	Update date 16 September 2020	Guidelines affected Red book
Change notification number 32-2020	Title Red Cells and Plasma, Leucocyte Depleted (PDF only, 404KB)	Update date 8 June 2020	Guidelines affected Red book
Change notification number 27-2020	Title Blood Tests (PDF only, 401KB)	Update date 7 May 2020	Guidelines affected Red book
Change notification number 25-2020	Title Fresh Frozen Plasma, Leucocyte Depleted (PDF only, 386KB)	Update date 5 May 2020	Guidelines affected Red book
Change notification number 23-2020	Title FFP for Neonates and Infants, Leucocyte Depleted (PDF only, 435KB)	Update date 4 May 2020	Guidelines affected Red book
Change notification number 24-2020	Title Cryoprecipitate for Neonates and Infants, Leucocyte Depleted (PDF only, 464KB)	Update date 4 May 2020	Guidelines affected Red book
Change notification number 19-2020	Title Annex 4 Redundant Components (PDF only, 389KB)	Update date 21 April 2020	Guidelines affected Red book
Change notification number 20-2020	Title Granulocytes Apheresis (PDF only, 391KB)	Update date 21 April 2020	Guidelines affected Red book
Change notification number 21-2020	Title Annex 5 Components for Contingency Use (PDF only, 389KB)	Update date 21 April 2020	Guidelines affected Red book
Change notification number 22-2020	Title Red Cells in Additive Solution, Leucocyte Depleted, Extended Shelf-Life (PDF only, 499KB)	Update date 21 April 2020	Guidelines affected Red book
Change notification number 34-2019	Title Platelets in Plasma and Additive Solution for Neonatal Use, Leucocyte Depleted (PDF only, 182KB)	Update date 26 November 2019	Guidelines affected Red book
Change notification number 10-2017	Title FFP and first-time donors (PDF only, 102KB)	Update date 6 April 2017	Guidelines affected Red book
Change notification number 01-2017	Title Chapter 11 Reagents Manufacture (PDF only, 106KB)	Update date 27 January 2017	Guidelines affected Red book
Change notification number 02-2017	Title Chapter 17 and Chapter 18 (PDF only, 114KB)	Update date 27 January 2017	Guidelines affected Red book
Change notification number 32-2016	Title Extended storage of frozen red cells (PDF only, 99KB)	Update date 15 August 2016	Guidelines affected Red book
Change notification number 33-2016	Title Removal of red cells from a controlled temperature (PDF only, 112KB)	Update date 15 August 2016	Guidelines affected Red book
Change notification number 34-2016	Title Upper limit of pH in platelets (PDF only, 107KB)	Update date 15 August 2016	Guidelines affected Red book
Change notification number 31-2016	Title Liquid Plasma, Leucocyte Depleted (PDF only, 118KB)	Update date 20 June 2016	Guidelines affected Red book