Hepatitis of unknown origin - Cord blood
Scenarios
Affected mother
- Obligatory
-
Must not donate if:
Less than 24 months from recovery.
- Discretionary
-
- If more than 12 months, but less than 24 months from recovery, obtain history and blood samples and refer to a Designated Clinical Support Officer.
- If more than 24 months from recovery, accept.
- Additional information
-
If more than 12 months and less than 24 months from recovery:
- If negative for all markers of hepatitis B, accept.
- If HB core antibody is positive and HBsAg is negative and HBV DNA is negative, accept.
Sexual partner of an affected individual
- Obligatory
-
Must not donate if:
Less than 12 months from recovery of partner.
Person sharing a home with an affected individual
- Obligatory
-
Must not donate if:
Less than 12 months from recovery of the last affected person in the home.
- See if relevant
-
- Sexual partner of and affected individual above
- Additional information
-
Most hepatitis of unknown origin will have been due to hepatitis A or hepatitis E (or non-viral causes). Additional testing for those who give a history of hepatitis between 12 and 24 months before donation will exclude the rare case of HBV which may have delayed clearance of infection and therefore will still present a risk through donation.
- Reason for change:
- Clarification regarding hepatitis B markers has been added to the additional information. To remove the requirement for anti-HBs levels to be >100 iu/l for acceptance of stem cell donations from donors who are anti-HBc-positive provided the HBV DNA result is negative.
- Version details:
CB-DSG Edition 203 Release 16 (31 March 2014)