Infection, chronic - Bone marrow and peripheral blood stem cell

Essential information

Obligatory

Must not donate.

Discretionary
  1. Acne:
    Most donors with acne can be accepted.

  2. Chronic fungal infections:
    1. If on local therapy for superficial infections only, accept.
    2. If on systemic antifungal treatment only for treatment of a localised, non-systemic fungal infection, and there are no complications, accept.
    3. If otherwise more than 7 days from completing systemic antifungal therapy, accept.

  3. Typhoid and paratyphoid:
    If more than 7 days from completion of antibiotic course and last symptoms, accept.

Supporting information

See if relevant
Additional information

Typhoid and paratyphoid are gastrointestinal infections which rarely have a chronic carrier state. It is usually caught while travelling. It is passed by the faecal-oral route and is not transmitted by tissue or cell transplantation.

Unusual bacterial/fungal/protozoal infections:

Specialist microbiological advice should be sought when considering using cells and tissues from donors who have had unusual infections in the past, including those acquired outside of Western Europe. This should include infections common in immunocompromised patients, or infections which lie dormant or may be difficult to eradicate.

Local fungal infections (e.g. nail infection or athlete’s foot):

Systemic oral antifungal treatment may be prescribed to treat localised fungal nail infections or athlete’s foot which are difficult to eradicate. Despite the systemic treatment, due to the fact that the infection is localised to the nails/digits, the risk to donated tissue/cells is considered to be remote.

Regulatory information

Part of this advice is a requirement of the EU Tissue and Cells Directive.

Reason for change:
To add guidance for acceptance of donors on oral antifungal treatment for localised nail infections or athlete’s foot.
Version details:

BM-DSG Edition 203 Release 38 (07 October 2020)